Musculoskeletal complications of haematological disease

Musculoskeletal complications of neuromuscular disease in children.

A wide variety of neuromuscular diseases affect children, including central nervous system disorders such as cerebral palsy and spinal cord injury; motor neuron disorders such as spinal muscular atrophy; peripheral nerve disorders such as Charcot-Marie-Tooth disease; neuromuscular junction disorders such as congenital myasthenia gravis; and muscle fiber disorders such as Duchenne's muscular dys...

Musculoskeletal Complications of Diabetes Mellitus

Diabetes may affect the musculoskeletal system in a variety of ways. The metabolic perturbations in diabetes (including glycosylation of proteins; microvascular abnormalities with damage to blood vessels and nerves; and collagen accumulation in skin and periarticular structures) result in changes in the connective tissue. Musculoskeletal complications are most commonly seen in patients with a l...

Prevention of the Musculoskeletal Complications of Hemophilia

Hemophilia is an inherited disorder of clotting factor deficiencies resulting in musculoskeletal bleeding, including hemarthroses, leading to musculoskeletal complications. The articular problems of hemophiliac patients begin in infancy. These include: recurrent hemarthroses, chronic synovitis, flexion deformities, hypertrophy of the growth epiphyses, damage to the articular cartilage, and hemo...

Musculoskeletal complications of haemophilia: the joint.

Drug-induced haematological disease.

The taunt about yesterday's remedies was that they were largely ineffectual. Today's treatment is often extremely effective but unfortunately has frequent bad effects, and much of modem therapeutic effort has to be directed at recognising and preventing morbidity from useful drugs. One group of organs that suffers much from drug-induced ills is the blood and the blood-forming tissues. In many h...